Titoli e pubblicazioni
Set – 2021
Challenges in the management of chronic wound infections
Falcone, M., De Angelis, B., Pea, F., Zanetti, O., Dalla Paola, L.
Chronic wound infections may delay the healing process and are responsible for a significant burden on healthcare systems. Since inappropriate management may commonly occur in the care of these patients, this review aims to provide a practical guide underlining actions to avoid in the management of chronic wound infections.
Archivio
Mag – 2021
Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute
De Angelis B, Balzani A, Pagnotta A, Tati E, Orlandi F, D’Autilio MFLM, Cervelli V, Gentile P.
Squamous cell carcinoma (SCC) is the second most common malignancy skin cancer. It is characterized by abnormal, accelerated growth of squamous cells (SCs). SCC occurs when DNA damage from exposure to ultraviolet radiation or other damaging agents trigger abnormal changes in the SCs, presenting as painless lesions on areas of high sun exposure, such as the dorsum of the hand and upper extremity.
Nov – 2020
Silver Sulfadiazine Eradicates Antibiotic-Tolerant Staphylococcus aureus and Pseudomonas aeruginosa Biofilms in Patients with Infected Diabetic Foot Ulcers
Enea Gino Di Domenico, Barbara De Angelis, Ilaria Cavallo, Francesca Sivori, Fabrizio Orlandi, Margarida Fernandes Lopes Morais D’Autilio, Chiara Di Segni, Pietro Gentile, Maria Giovanna Scioli, Augusto Orlandi, Giovanna D’Agosto, Elisabetta Trento, Daniela Kovacs, Giorgia Cardinali, Annunziata Stefanile, Tatiana Koudriavtseva, Grazia Prignano, Fulvia Pimpinelli, Ilaria Lesnoni La Parola, Luigi Toma, Valerio Cervelli, Fabrizio Ensoli
Infections are among the most frequent and challenging events in diabetic foot ulcers (DFUs). Pathogenic bacteria growing in biofilms within host tissue are highly tolerant to environmental and chemical agents, including antibiotics.
Gen – 2020
Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation
Pietro Gentile, Claudio Calabrese, Barbara De Angelis, Laura Dionisi, Jacopo Pizzicannella, Ashutosh Kothari, Domenico De Fazio, Simone Garcovich
Autologous therapies using platelet-rich plasma (PRP) need meticulous preparation-currently, no standardised preparation technique exists. Processing Quantitative Standards (PQSs) define manufacturing quantitative variables (such as time, volume and pressure).
Set – 2020
Randomized Blinded Retrospective Study: the combined use of Micro-needling Technique, Low-Level Laser Therapy and Autologous Non-Activated Platelet-Rich Plasma improves Hair Re-Growth in patients with Androgenic Alopecia
Gentile, P., Dionisi, L., Pizzicannella, J., De Angelis B…De Fazio, D., Garcovich, S.
Mini-invasive therapies based on autologous non-activated Platelet-Rich Plasma (ANA-PRP), Low-Level Laser Therapy (LLL-T), and Micro-Needling Technique (MN-T) used in combining for hair re-growth need to be standardized.
Set – 2020
Regenerative application of stromal vascular fraction cells enhanced fat graft maintenance: clinical assessment in face rejuvenation
Gentile, P., Sterodimas, A., Calabrese, C., De Angelis B…De Fazio, D., Garcovich, S.
The aim of this study was to evaluate the safety and efficacy of the use of FG-SVFs in face rejuvenation for esthetic improvement.
Nov – 2019
Impact of the Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells (AD-SVFs) and Human Adipose-Derived Mesenchymal Stem Cells (AD-MSCs): Enzymatic Digestion Versus Mechanical Centrifugation
Pietro Gentile, Claudio Calabrese, Barbara De Angelis, Jacopo Pizzicannella, Ashutosh Kothari, Simone Garcovich
Autologous therapies using adipose-derived stromal vascular fraction (AD-SVFs) and adult adipose-derived mesenchymal stem cells (AD-MSCs) warrant careful preparation of the harvested adipose tissue.
Set – 2019
Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers
Gentile P, De Angelis B, Pasin M, Cervelli G, Curcio CB, Floris M, Di Pasquali C, Bocchini I, Balzani A, Nicoli F, Insalaco C, Tati E, Lucarini L, Palla L, Pascali M, De Logu P, Di Segni C, Bottini DJ, Cervelli V. ; J Craniofac Surg. 2014 Jan;25(1):267-72.
Actually, autologous fat grafts have many clinical applications in breast surgery, facial rejuvenation, buttock augmentation, and Romberg syndrome as well as a treatment of liposuction sequelae.
Apr – 2019
Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute
Barbara De Angelis, Pietro Gentile, Eleonora Tati, Davide J. Bottini, Fabrizio Orlandi, Giampiero Pepe, Valerio Cervelli, Ilaria Bocchini, Giulio Cervelli. Chiara Di Segni “BioMed Research International”
he healing of venous and arterial ulcers is slow, and in some cases, they may not heal at all. This study aims to demonstrate the clinical advantage of Nevelia®, an innovative collagen dermal template substitute (DS) in venous and arterial chronic ulcers treatment.
Apr – 2019
Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation
Gentile P, Scioli MG, Bielli A, De Angelis B, De Sio C, De Fazio D, Ceccarelli G, Trivisonno A, Orlandi A, Cervelli V, Garcovich S.
Platelet rich plasma (PRP) and Micrografts containing human follicle mesenchymal stem cells (HF-MSCs) were tried as a potential treatment for androgenetic alopecia (AGA). However, little to no work has yet to be seen wherein the bio-molecular pathway of HF-MSCs or PRP treatments were analyzed.
Gen – 2019
Recessive mutations in the neuronal isoforms of DST, encoding dystonin, lead to abnormal actin cytoskeleton organization and HSAN type VI
Fortugno P, Angelucci F, Cestra G, Camerota L, Ferraro AS5 Cordisco S, Uccioli L, Castiglia D, De Angelis B, Kurth I, Kornak U, Brancati F
Hereditary sensory and autonomic neuropathies (HSAN) are clinically and genetically heterogeneous disorders, characterized by a progressive sensory neuropathy often complicated by ulcers and amputations, with variable motor and autonomic involvement.
Ott – 2018
Long-term follow-up comparison of two different bi-layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings.
De Angelis B, Orlandi F, Fernandes Lopes Morais D’Autilio M, Scioli MG, Orlandi A, Cervelli V , Gentile P
Double layer dermal substitute (DS) consist of a 3-dimensional collagen structures and a superficial silicon layer that are positioned within the defect provide to promote tissue regeneration in skin wounds. DS often have unique physical characteristics due to differences in manufacturing techniques. The aim of this study is the clinical and histological comparison of Nevelia and Integra double layer DSs in patients with post-traumatic injury wounds.
Lug – Set 2018
Gentle Is Better: The Original “Gentle Technique” for Fat Placement in Breast Lipofilling
Pietro Gentile, MD, PhD, Barbara De Angelis, Verdiana Di Pietro, Vittoria Amorosi, Maria G. Scioli, Augusto Orlandi, and Valerio Cervelli
Breast lipofilling usually involves three different stages (harvesting, processing, and placement), and in each of these phases, adipocyte cells can be damaged. Our technique of fat placement is quite different from the others as we focus our attention on the last stage of fat graft procedure, which could explain the better results in graft survival.
Gen – 2018
The survey on cellular and tissue-engineered therapies in Europe and neighboring Eurasian countries in 2014 and 2015
Ireland H, Gay MHP, Baldomero H, De Angelis B, Baharvand H, Lowdell MW, Passweg J, Martin I; International Society for Cellular Therapy (ISCT); Tissue Engineering and Regenerative Medicine International Society—Europe (TERMIS-EU); International Cartilage Repair S
With the support of five established scientific organizations, this report, the seventh of its kind, describes activity in Europe for the years 2014 and 2015 in the area of cellular and tissue-engineered therapies, excluding hematopoietic stem cell (HSC) treatments for the reconstitution of hematopoiesis.
Ago – 2016
Obesity phenotypes and resorption percentage after breast autologous fat grafting: Rule of low-grade inflammation
Gentile P, Sarlo F, De Angelis B, De Lorenzo A, Cervelli V.
One of the main reasons why the breast fat grafting was questioned is that there may be lipofilling resorption. In the literature, the resorption rate reported over the 1(st) year is highly variable (20-90%).
Gen – 2016
Use of Platelet Rich Plasma (PRP) and Hyaluronic Acid in Treatment of Extremity Gunshot Injuries: A CaseReport
Gentile P, Sarlo F, De Angelis B, De Lorenzo A, Cervelli V.
In the view of efficiency and cost effectiveness the increasing incidence of gunshot wounds demands a modification of treatment protocols. The general basis are antibiotics, fracture stabilization and debridement of soft tissue injuries. The pathology of gunshot wounds and established treatment algorithm however have to be adjusted to the ongoing development of gun technology and the thereby caused specific lesions.
Nov – 2015
One-stage reconstruction of scalp after full thickness oncologic defects using a Dermal Regeneration Template (Integra®)
Barbara De Angelis, Pietro Gentile, Eleonora Tati, Davide J. Bottini, Fabrizio Orlandi, Giampiero Pepe, Valerio Cervelli, Ilaria Bocchini, Giulio Cervelli. Chiara Di Segni “BioMed Research International”
The use of Dermal Regeneration Template (DRT) can be a valid alternative for scalp reconstruction, especially in elderly patients where a rapid procedure with an acceptable aesthetic and reliable functional outcome is required.
Ott – 2014
LIMB RESCUE: A NEW AUTOLOGOUS-PERIPHERAL BLOOD MONONUCLEAR CELLS TECHNOLOGY IN CRITICAL LIMB ISCHEMIA AND CHRONIC ULCERS.
De Angelis B, Gentile P, Orlandi F, Bocchini I, Di Pasquali C, Agovino A, Gizzi C, Patrizi F, Scioli MG, Orlandi A, Cervelli V. Tissue Eng Part C Methods. 2014 Oct 23
Therapeutic angiogenesis by autologous-peripheral blood mononuclear cells (A-PBMNC) implantation has been shown to be a safe and effective treatment for critical limb ischemia (CLI).
Gen – 2014
Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical evaluation for cell-based therapies in patients with scars on the face.
Gentile P, De Angelis B, Pasin M, Cervelli G, Curcio CB, Floris M, Di Pasquali C, Bocchini I, Balzani A, Nicoli F, Insalaco C, Tati E, Lucarini L, Palla L, Pascali M, De Logu P, Di Segni C, Bottini DJ, Cervelli V. ; J Craniofac Surg. 2014 Jan;25(1):267-72.
Actually, autologous fat grafts have many clinical applications in breast surgery, facial rejuvenation, buttock augmentation, and Romberg syndrome as well as a treatment of liposuction sequelae.
Dic – 2013
The use of infrared radiation in the treatment of skin laxity.
Felici M, Gentile P, De Angelis B, Puccio L, Puglisi A, Felici A, Delogu P, Cervelli V. J Cosmet Laser Ther. 2013 Dec 14.
Cosmetic surgery and medicine are extremely interesting fields for a plastic surgeon. Lasers and lights determine ablation, contraction and regenerating stimulus in skin tissues. The aim of this study is to examine the use of infrared lights in treating facial and body skin laxity.
Set – 2013
P.R.L. platelet rich lipotransfert: our experience and current state of art in the combined use of fat and PRP.
Cervelli V, Bocchini I, Di Pasquali C, De Angelis B, Cervelli G, Curcio CB, Orlandi A, Scioli MG, Tati E, Delogu P, Gentile P. Biomed Res Int. 2013;2013:434191.
The authors report their experience about the use of P.R.L. PLATELET RICH LIPOTRANSFERT method (platelet rich plasma mixed fat grafting) in 223 patients affected by soft tissue defects (ulcers, Romberg syndrome, Hemifacial atrophy, loss of substance, and signs of aging).
Ago – 2013
Chronic ulcers: MATRIDERM(®) system in smoker, cardiopathic, and diabetic patients.
De Angelis B, Gentile P, Agovino A, Migner A, Orlandi F, Delogu P, Cervelli V. J Tissue Eng. 2013 Aug 26
Diabetic ulcers and pressure ulcers represent a more frequent cause of chronic wounds in aging populations. It is estimated that approximately 15% of the diabetic population will develop diabetic ulcers during their life and over half of these patients develop an infection, often osteomyelitis, with 20% requiring amputation.
Feb – 2013
The use of a non cultured autologous cell suspension to repair chronic ulcers.
De Angelis B, Migner A, Lucarini L, Agovino A, Cervelli V. Int Wound J. 2013 Feb 28.
The purpose of this uncontrolled study was to evaluate the clinical effectiveness of ReCell(®) system in the treatment of chronic ulcers. From October 2011 to July 2012, 20 patients, 8 men and 12 women with a mean age of 70 years, with chronic ulcers of different aetiology that were unresponsive to conventional therapies were recruited and treated using the ReCell(®) system.
Set – 2012
Spontaneous clostridial myonecrosis after pregnancy - emergency treatment to the limb salvage and functional recovery: a case report.
De Angelis B, Cerulli P, Lucilla L, Fusco A, Di Pasquali C, Bocchini I, Orlandi F, Agovino A, Cervelli V. Int Wound J. 2012 Sep 13
Clostridial myonecrosis (CM) is a rare, life threatening necrotizing infection of a skeletal muscle caused by Clostridium perfringens in the majority of cases. The diagnosis may be difficult because of few diagnostic and cutaneous signs early in its course.
Giu – 2012
Regenerative surgery of the complications with Morton's neuroma surgery: use of platelet rich plasma and hyaluronic acid.
De Angelis B, Lucarini L, Orlandi F, Agovino A, Migner A, Cervelli V, Izzo V, Curcio C. Int Wound J. 2012 Jun 14
Morton’s neuroma is an entrapment neuropathy of the plantar digital nerve. We treated five patients with wound dehiscence and tendon exposure, after Morton’s neuroma surgery excision using a dorsal approach.
Mag – 2012
Combined use of super-oxidised solution with negative pressure for the treatment of pressure ulcers: case report.
de Angelis B, Lucarini L, Agovino A, Migner A, Orlandi F, Floris M, Cervelli V, Curcio C. Int Wound J. 2012 May 24
A 61-year-old patient was affected by flaccid paraplegia for 20 years because of post-traumatic medullar injury caused by an accidental fall, with stage IV sacral pressure ulcer for 3 years.
Ago – 2011
Skin necrosis of scrotum due to endovascular embolisation: a case report.
Cervelli V, Brinci L, Palla L, Spallone D, Izzo V, Curcio CB, Lucarini L, De Angelis B. Int Wound J. 2012 Feb;9(1):70-5. doi: 10.1111/j.1742-481X.2011.00847.x. Epub 2011 Aug 31.
The aim of our case report was to analyse the results obtained with the Matriderm® system and autologous skin grafting for the surgical treatment of skin necrosis of scrotum as a result of endovascular embolisation.
Mag – 2011
The use of MatriDerm® and skin grafting in post-traumatic wounds.
Cervelli V, Brinci L, Spallone D, Tati E, Palla L, Lucarini L, De Angelis B. Int Wound J. 2011 Aug;8(4):400-5. doi: 10.1111/j.1742-481X.2011.00806.x. Epub 2011 May 12.
The aim of this study was to prove the effectiveness of MatriDerm(®) combined with skin grafting versus skin grafting alone in post-traumatic wounds treatment. At the Department of Plastic and Reconstructive Surgery of the University of Rome Tor Vergata, we treated 60 patients.
Apr – 2011
Use of platelet-rich plasma and hyaluronic Acid in the loss of substance with bone exposure.
Cervelli V, Lucarini L, Spallone D, Palla L, Colicchia GM, Gentile P, De Angelis B. Adv Skin Wound Care. 2011 Apr;24(4):176-81.
In lower-extremity surgery, the complex wound with bone exposure remains a challenging problem for the plastic surgeon. The purpose of this study was to describe a new therapeutic approach to stimulate the regeneration of the lower-extremity complex wounds based on a combined treatment composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) dressing.
Nov – 2010
Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers.
Cervelli V, Gentile P, De Angelis B, Calabrese C, Di Stefani A, Scioli MG, Curcio BC, Felici M, Orlandi A. Stem Cell Res. 2010 Nov 30.
The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups.
Ago – 2010
Treatment of stable vitiligo hands by ReCell system: a preliminary report.
Cervelli V, Spallone D, Lucarini L, Palla L, Brinci L, De Angelis B. Eur Rev Med Pharmacol Sci. 2010 Aug;14(8):691-4.
The aim of this study was to prove the effectiveness of MatriDerm(®) combined with skin grafting versus skin grafting alone in post-traumatic wounds treatment. At the Department of Plastic and Reconstructive Surgery of the University of Rome Tor Vergata, we treated 60 patients.
Giu – 2010
The use of Matriderm and autologous skin grafting in the treatment of diabetic ulcers: a case report.
Cervelli V, Lucarini L, Cerretani C, Spallone D, Palla L, Brinci L, De Angelis B. Int Wound J. 2010 Aug;7(4):291-6. Epub 2010 Jun 8.
The aim of our case report was to analyse the results obtained with the Matriderm system and autologous skin grafting for the surgical treatment of diabetic ulcers. We recruited one patient with diabetic ulcers admitted at the Department of Plastic and Reconstructive Surgery, University of Rome ‘Tor Vergata’.
Mag – 2010
A case of labial fusion and urinary pseudo-incontinence in an elderly woman. A surgical treatment and a review.
Palla L, De Angelis B, Lucarini L, Spallone D, Palla G, Cervelli V. Eur Rev Med Pharmacol Sci. 2010 May;14(5):491-3. Review.
Labial fusion is defined as either partial or complete adherence of the labia minora, and also called vulvar fusion, adhesions of the labia minor or conglutination of the labia minora and sinechia of the vulva.
Mag – 2010
Use of platelet rich plasma and hyaluronic acid on exposed tendons of the foot and ankle.
Cervelli V, Lucarini L, Spallone D, Brinci L, de Angelis B. J Wound Care. 2010 May;19(5):186, 188-90.
Platelet rich plasma was used as an autologous scaffold for cellular growth, in combination with hyaluronic acid as a temporary dermal substitute. This aided healing of acute and chronic open wounds of the foot and ankle.
Giu – 2010
The use of Matriderm and autologous skin grafting in the treatment of diabetic ulcers: a case report.
Cervelli V, Lucarini L, Cerretani C, Spallone D, Palla L, Brinci L, De Angelis B. Int Wound J. 2010 Aug;7(4):291-6. Epub 2010 Jun 8.
The aim of our case report was to analyse the results obtained with the Matriderm system and autologous skin grafting for the surgical treatment of diabetic ulcers. We recruited one patient with diabetic ulcers admitted at the Department of Plastic and Reconstructive Surgery, University of Rome ‘Tor Vergata’.
Mag – 2010
A case of labial fusion and urinary pseudo-incontinence in an elderly woman. A surgical treatment and a review.
Palla L, De Angelis B, Lucarini L, Spallone D, Palla G, Cervelli V. Eur Rev Med Pharmacol Sci. 2010 May;14(5):491-3. Review.
Labial fusion is defined as either partial or complete adherence of the labia minora, and also called vulvar fusion, adhesions of the labia minor or conglutination of the labia minora and sinechia of the vulva.
Mag – 2010
Use of platelet rich plasma and hyaluronic acid on exposed tendons of the foot and ankle.
Cervelli V, Lucarini L, Spallone D, Brinci L, de Angelis B. J Wound Care. 2010 May;19(5):186, 188-90.
Platelet rich plasma was used as an autologous scaffold for cellular growth, in combination with hyaluronic acid as a temporary dermal substitute. This aided healing of acute and chronic open wounds of the foot and ankle.
Ott – 2010
Use of a novel autologous cell-harvesting device to promote epithelialization and enhance appropriate pigmentation in scar reconstruction.
Cervelli V, De Angelis B, Spallone D, Lucarini L, Arpino A, Balzani A. Clin Exp Dermatol. 2010 Oct;35(7):776-80.
Epidermal replacement is an important step in the management of patients with post-traumatic and iatrogenic scars. Skin-colour variation from disease or trauma causes significant changes in self-image and appearance.
Giu – 2010
Tissue regeneration in loss of substance on the lower limbs through use of platelet-rich plasma, stem cells from adipose tissue, and hyaluronic acid.
Cervelli V, De Angelis B, Lucarini L, Spallone D, Balzani A, Palla L, Gentile P, Cerulli P. Adv Skin Wound Care. 2010 Jun;23(6):262-72.
Platelet-rich plasma (PRP) induces wound regeneration and tissue repair through cell proliferation and differentiation, promoting tissue healing and also acting as an autologous scaffold.
2009
Treatment of stable vitiligo by ReCell system.
Cervelli V, De Angelis B, Balzani A, Colicchia G, Spallone D, Grimaldi M. Acta Dermatovenerol Croat. 2009;17(4):273-8.
The aim of our study was to analyze the results obtained with the ReCell system for surgical treatment of stable vitiligo. At Department of Plastic and Reconstructive surgery, University of Tor Vergata in Rome, we treated 15 patients with stable vitiligo during a 2-year period.
Set – 2007
A randomized trial comparing ReCell system of epidermal cells delivery versus classic skin grafts for the treatment of deep partial thickness burns.
Gravante G, Di Fede MC, Araco A, Grimaldi M, De Angelis B, Arpino A, Cervelli V, Montone A. Burns. 2007 Dec;33(8):966-72. Epub 2007 Sep 29.
Our purpose was to directly compare results obtained with the ReCell system and the classic skin grafting for epidermal replacement in deep partial thickness burns.
Mar – 2006
Traumas of the middle skull base with TMJ involvement. Case report.
Bottini DJ, Gnoni G, De Angelis B, Savo P, Trimarco A, Cervelli G, Cervelli V. Minerva Stomatol. 2006 Mar;55(3):151-7. English, Italian. Riv Chir Mano – Vol. 43 (3) 2006
The authors report their experience with temporomandibular joint (TMJ) traumas involving breakage of the roof of the glenoid cavity, an infrequent event that occurs in those cases in which, as a result of the condylar neck not fracturing, the traumatic energy is transmitted to the middle skull base.